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Inhibitors like FK866 and CHS828, which are based on heterocyclic structures and act by binding to the active site of NAMPT 215,216 , are being investigated for their potential to selectively target cancer cells by exploiting their high NAD + turnover 214

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Taken together, the preclinical studies converge on a reproducible signal: in obese rodents, AOD-9604 reduces fat accumulation, increases fat oxidation and lipolysis, and spares insulin sensitivity and IGF-1