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A randomized double-blind clinical trial on safety and efficacy of tauroursodeoxycholic acid (TUDCA) as add-on treatment in patients affected by amyotrophic lateral sclerosis (ALS): the statistical analysis plan of TUDCA-ALS trial

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The phenomenon of anaphylaxis was discovered by Portier and Richet in 1903.[1,2] They injected dogs with toxins from sea anemone with the intent of generating protective antibodies

DOI: 10.1155/2019/3150145

Moreover, LPs can be extra equipped with functional moieties to increase their performances in terms of increased circulation half-life, targeted delivery, and intracellular permeation capability (Kim, 2016)

Up to date, there are no genotypes or phenotypes associated with responders to these interventions