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Metabolic targets in TC therapy While thyroidectomy, radioiodine therapy and TSH suppression make up the mainstream of TC treatment, targeted therapies restraining pathways involved with MAPK, PI3K/AKT/mTOR or VEGF are on the rise [257,258,259]

International Journal of Biological Research, 5 (1), 2124

For example, the nuclear receptors CAR and PXR, as cardiovascular metabolic regulators, have garnered attention for their roles in lipid and glucose homeostasis, blood pressure regulation, and atherosclerosis ( 5.2 Current research challenges and limitations Although the sex hormone-ferroptosis regulatory axis offers a promising theoretical framework for understanding sex differences in AS, we must acknowledge the significan challenges and inherent limitations of current research

Itaconate produced by macrophages has antimicrobial activity which is crucial in the killing of phagocytosed bacteria

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On the contrary, Slc7a5 -null CD4 + T cells manifest reduced methionine influx and impaired differentiation following T cell receptor (TCR, CD3/CD28) stimulation (9)