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The dysregulation of ROS and GSH balance can tip the scales toward an oxidatively stressed microenvironment, contributing to the transformation and survival of cancerous cells
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For example, in a resting state, glycogen synthase kinase-3 (GSK-3) phosphorylates NRF2, creating a site recognized by the E3 ligase adapter beta-transducin repeat-containing protein (-TrCP)

P., Huiskonen, J

Cancers (Basel.)

GST- protein and mRNA levels are significantly reduced in both cell lines [1]