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To validate NNMT as an anti-obesity drug target, we investigated the permeability, selectivity, mechanistic, and physiological properties of a series of small molecule NNMT inhibitors

The 30% body weight reduction in 28 days was achieved at doses optimized for the mouse model

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No severe headaches were reported, and no participant discontinued due to this symptom

Patients randomized to metformin therapy in the Diabetes Prevention Program Outcome Study were more likely to show vitamin B12 deficiency or borderline low vitamin B12 levels (19)