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Subsequently, studies conducted in vitro indicate that defective proteasome activity disturbs A degradation consistent with accumulation of this neurotoxic peptide and plaque formation (352)

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Hu MC, Shi M, Gillings N, Flores B, Takahashi M, Kuro-o M, Moe OW (2017) Recombinant -klotho may be prophylactic and therapeutic for acute to chronic kidney disease progression and uremic cardiomyopathy

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Six animals per each experimental group and time interval were used

SIRT3 inhibits gallbladder cancer by induction of AKT-dependent ferroptosis and blockade of epithelial-mesenchymal transition