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Conflict of Interest The authors have declared that no conflict of interest exists

Originally approved by the FDA in 1959, it has remained one of the most widely prescribed weight loss medications in the United States for decades

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Goal: Inhibit NNMT to raise intracellular NAD+ and activate SIRT1, theorized to support fat metabolism and preserve lean mass effects reported in animal and cell studies, not established in humans [1] [5]