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The illness is characterized by gradual loss of dopaminergic neurons in the substantia nigra and the appearance of Lewy bodies, which include aggregation of alpha-synuclein, extensively dispersed proteins in the cerebral tissues

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I fully agree that innovation in longevity medicine is important, but I wonder whether experimentation outside controlled research settings could put individuals at unnecessary risk

However, numerous studies have reported that increased intestinal permeability often precedes the onset of T1D-associated symptoms suggesting that disruption of gut barrier integrity may have an aetiological role in T1D or at least contribute to disease pathogenesis (Meddings et al

2e ~ e), eventually returning to healthy control levels in the 13w group (Fig