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Its pathophysiology involves several mechanisms: Persistent hyperglycemia, along with toxic substrates, affects multiple cells in the peripheral nervous system, including Schwann cells, axons, and neurons in the dorsal root ganglion, as well as vascular cells

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Molecular mechanisms and the role of autophagy in promoting lipid peroxidation The consumption of fat and lipids have been shown to impact autophagy and ferroptosis regulation in different diseases, especially in prostate and liver cancer cells [2, 73]

In pregnancy, ROS are generated mainly in the placenta, but xanthine oxidase (XO) are present in the vascular endothelium, and nitric oxide synthase (NOS) are also sources of ROS [15]

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N-Acetyl Cysteine (NAC): Promotes the bodys natural production of glutathione, enhancing overall health and immune support