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250 A recent in vitro study has found that butyrate stimulated adenosine triphosphate release from astrocytes in a cytosolic Ca 2+ -dependent manner, suggesting a potential neuroprotective mechanism worth further exploration

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NTD The NTD accounts for more than half of the size of the AR (residues 1555), and its entirety is encoded by exon 1

(Source 3) Glutathione supplementation supports gut function and microbiome balance

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Hence, this loss of critical proteins has the potential to compromise ER proteostasis and generate cellular stress