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[DOI] [PubMed] [Google Scholar] 89.Groenestege WM, Thebault S, van der Wijst J, et al

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Subsequent post-hoc analysis revealed a significant difference between 24 h untreated and LPC-treated slices at 24 h (LPC: 54.10% 7.39%, p = 0.0001), 72 h (LPC: 58.24% 1.76%, p = 0.000002), 1 week (LPC: 50.5% 5.03%, p = 0.000002), 3 weeks (LPC: 67.95% 3.25%, p = 0.0001) and 5 weeks (LPC: 76.43% 6.83%, p = 0.024) post-treatment (Figure 5E)

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These results revealed that microglia-derived TNF induced COX2 and PGIS expression in spinal endothelial cells and that endothelial PGI2 played a critical role in neuropathic pain via neuronal IP receptor

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