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Kidney, Heart and Brain: Three Organs Targeted by Ageing and Glycation
Asian J Pharm Clin Res
[DOI] [PMC free article] [PubMed] [Google Scholar] 88.Onaolapo O.J., Adekola M.A., Azeez T.O
K., Shetty A
Chronic stress elevates cortisol, which directly suppresses glutathione synthesis via inhibition of gamma-glutamylcysteine synthetase (GCS), the rate-limiting enzyme in glutathione production
In conclusion, these findings demonstrate the far-reaching consequences of ROS on the fundamental genetic molecules of life, encompassing synthesis, decomposition, and damage repair
