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Symptoms can include: Muscle weakness or cramping Irregular heartbeat Unusual tiredness

Deficiency may present as fatigue, neuropathy, cognitive changes, or gastrointestinal symptoms related to malabsorption

Obese mice and rats treated with AOD9604 showed significant decreases in adipose tissue depot weights, reductions in adipocyte size observed histologically, and improvements in body composition measured by DEXA scanning or MRI

Intrauterine growth retardation and consequences for endocrine and cardiovascular diseases in adult life: Does insulin-like growth factor-I play a role

Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins

References to biological effects are limited to research context only and must not be interpreted as claims of therapeutic, diagnostic, or clinical benefit