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The glucagon component may contribute an additional vasodilatory effect that amplifies the blood pressure benefit relative to GLP-1-only compounds

Active eating disorders represent a relative contraindication

Neurogenesis in adult animals has also been observed under physiological conditions in the mouse intestine after treatment with a 5-HT 4 receptor agonist (490) and in the mouse ileum (644) and in rat and guinea pig rectum (494, 645) after an anastomosis and treatment with a 5-HT 4 receptor agonist

These two peptides work through different but complementary pathways

Koussoulas, K., Gwynne, R
