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Nevertheless, as discussed above, an abnormal postmethionine-load homocysteine elevation above fasting levels must be taken into account in the general identification of patients bearing transsulfuration defects, such as vitamin B 6 -deficient subjects or heterozygotes for CBS deficiency

The most robust effort to date, an analysis of over 1,000 tumors across 10 tumor subtypes using CPTAC proteogenomics data, identified that mutations in Keap1 and NRF2 were associated with diminished IFN and CD8 T cells [62]

Details of the primary and secondary antibodies used in the Western blotting experiments can be found in Supplementary Table 3

For example, more than 30% of cell in AGS cellular models of ADAR mutation are accumulating dsRNA but less than 16% showed accumulation of dsDNA structures in the cytosol, coherent with its role of RNA editing (figure S5J)