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A systematic spatial transcriptomic atlas of non-fibrotic aging muscle has yet to be reported, in part owing to current limitations in resolution and transcript-detection sensitivity, as well as challenges in distinguishing MuSCs from closely neighboring cell types in situ

44 The other invasive approach, temporarily opening the BBB, necessitates collaboration with highly trained neurosurgeons and it may cause potential adverse effects from BBB disruption, such as hemorrhage and brain damage or inflammation