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IHC staining revealed that Ferritin was diffusely distributed in the cytoplasm of tubular epithelial cells of the control mice, while Ferritin was significantly downregulated in FA-injected mice, which was reversed by LA supplementation

In addition, because the levels of acetaldehyde in the blood of these individuals rises rapidly following alcohol consumption it leads to the highly adverse reactions to this compound that includes severe flushing, nausea, and tachycardia

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and in the decision to submit the article for publication

Overall, these results indicate that the regulation of ferroptosis sensitivity by IRE1 can be modulated pharmacologically

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