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Although research remains at the preclinical animal stage, the product has become an important tool for dissecting glucose metabolism disorders and diabetes and developing novel hypoglycemic agents, with its key advantage lying in nicotinamide pathway regulation and NAD+ stabilization

Numerous incidences have occurred when a high dose of Vitamin B12 (in the form of supplements or injections) has caused acne breakouts in susceptible or even healthy individuals

But dark yellow urine could be a sign of dehydration

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After the initial treatment period, maintenance doses may be given less frequently

However, three major reviews didnt show sufficient evidence to support this claim (14, 15, 16)