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However, in line with our observation of elevated ser/gly synthesis in HIF2 KO NSCLC cells, HIF2 deficient renal cell carcinoma (RCC) cells showed upregulation of ser/gly synthesis pathway and presented enhanced sensitivity to the inhibition of this pathway using the phosphoglycerate dehydrogenase (PHGDH) inhibitor NCT-503 [57]

doi: 10.1016/j.biortech.2017.09.117

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