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Patients may experience nausea, vomiting, and dumping syndrome

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Methotrexate, a dihydrofolate reductase and aminoimidazole-4-carboxamide ribonucleotide transformylase inhibitor, serves as the first-line treatment for RA due to its efficacy and accessibility

Also, monitor patients for new or worsening psychiatric symptoms during concomitant treatment with other drugs that are associated with similar psychiatric effects [see Drug Interactions (7.1)]
