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Additionally, the exogenous administration of melatonin has been shown to increase the expression of suppressors of cytokine signaling, thus enhancing the immune response and contributing to the anti-aging effects of this compound (Tresguerres et al., 2012

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The mRNA expression levels of PGC-1, Nrf2 and TFAM in the periodontitis group decreased and showed a higher level of apoptosis (57), which clearly proved that the aggravation of mitochondrial OS might interfere with the enhancement of periodontal cell apoptosis in diabetic periodontitis