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Furthermore, concomitant medication use fell from 30% to 8% between weeks two and four of the study, primarily relating to analgesic or muscle-relaxing drugs [21]

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Clinical outcomes vary widely depending on patient profile, training consistency, and adherence to treatment protocols

A less common long-term complication is permanent facial weakness with muscle contractures

Individual Variation Genetic polymorphisms in the beta-3 adrenergic receptor (ADRB3) affect how strongly individuals respond to beta-3 pathway stimulation