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An open label extension study means you may be able to continue taking the investigational study drug, if you qualify and choose to participate

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31 Phenformin has been reported to exhibit anti-thiamine activity in animals, 3234 and as a result, it has been suggested that a possible anti-thiamine effect of metformin might contribute to some cases of metformin-associated lactic acidosis, a rare condition, but one that has been shown to have a mortality rate of 1825%

doi: 10.1016/j.bbi.2009.06.001

Phase I study of MRX34, a liposomal miR-34a mimic, administered twice weekly in patients with advanced solid tumors