hif-2α glutathione Hypoxia, oxidative stress, and the interplay of HIFs and NRF2 signaling in cancer 2α Translation Inhibitor Redox imbalance and hypoxia‐inducible factors:
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The peptide space has had plenty of demand

Abstract The growth hormone secretagogue receptor (GHSR1a), the target of the ghrelin peptide, is widely distributed throughout the brain, and, while studies have often reported very low or absent levels of central ghrelin, it is now known that GHSR1a, even in the absence of a natural ligand, has physiological roles

[PubMed 17156593] 2709

As noted, before TRs can work, they must attach themselves to another receptor called RXR
