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Figure 1 Evidence-based effects of key nutrients After understanding the pathological connection between nutrients and OA and discovering the significant role of the metabolism-inflammation-oxidative stress network in it, this study explores key nutrients that can prevent or treat OA through evidence-based medicine and reveals the mechanisms by which they exert preventive or therapeutic effects (Table 1)

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For instance, for injections performed on both sides of one vertebral level, report the base injection code (64490 or 64493) with modifier 50 Bilateral procedure