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Earlier study suggests that activation of NLRP3 is elicited within hours of ischemic stroke onset, driving neuroinflammation, ultimately leading to neuronal death ( Of note, there are still limitations in current study

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Samples were transferred onto 0.5 m-thick silicon nitride (Si 3 N 4 ) window (Silson), excess buffer wicked away and then the slide was frozen in situ under a laminar stream of 100 K dry nitrogen (N 2 ) gas

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