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The ability to acquire choline and amino acids from the diet and to salvage the purine nucleotides makes the role of 5,10-methylene-THF, in dTMP synthesis, one of the most significant metabolic functions for dietary folate

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This is the theoretical basis for endogenously supplied gamma-glutamylcysteines ability to raise GSH levels, as being the product of the GCL enzyme, it can be taken up by cells intact, where it feeds directly into glutathione synthase to be converted to glutathione, effectively bypassing the dysfunctional GCL

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Acknowledgements We would like to thank the technicians at pharmacology department, Faculty of Medicine, Minia University, who helped us deal with mice

Glutamate transporters and the excitotoxic path to motor neuron degeneration in amyotrophic lateral sclerosis