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Berberine also induces apoptosis via the mitochondrial pathway, promoting the release of cytochrome c from mitochondria, activating caspase-8, 9, and subsequent caspase-3 cascades, and triggering apoptosis by inhibiting the expression of Bcl-2 while increasing pro-apoptotic proteins (85)

Evans blue extravasation refers to the potential leakage of Evans blue dye from blood vessels into the surrounding tissues, which potentially indicates increased vascular permeability, possibly associated with inflammation

[DOI] [PubMed] [Google Scholar] 87.Moreno C., Langlet P., Hittelet A., Lasser L., Degre D., Evrard S., Colle I., Lemmers A., Deviere J., Le Moine O

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References Ashby J et al (1989) Inactivity of ethyl acrylate in the mouse bone marrow micronucleus assay