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[DOI] [PMC free article] [PubMed] [Google Scholar] 42.Sonntag, T

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It declines with age, and lower NAD+ is associated with slower metabolism and the changes we lump together as getting older. NNMT, meanwhile, consumes the raw materials your body uses to make NAD+ and in fat tissue, NNMT is often overexpressed, which can drag NAD+ down right where you least want a sluggish metabolism

Together these results argue that it has to be an optimal balance between endogenous thiols and ROS to lengthen the lifespan

Vopr Pitan 2020, 89 (5), 616