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In conclusion, these studies showed an effect of APOE on L-carnitine, its metabolites and acylcarnitines with age in the brain parenchyma and in the cerebrovasculature up to mid-life, which suggest differences in age-related bioenergetic shift between alleles

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Vegan and vegetarian Other popular diets aimed at improving overall health include the vegan and vegetarian diets, which have been studied in the context of TMAO, as some of its precursors are significantly decreased in these diets

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The latter is defined as failure of adequate trials of two tolerated, appropriately chosen and used antiepileptic drug (AED) schedules (whether as monotherapies or in combination) to achieve sustained seizure freedom 2