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Nat Rev Mol Cell Biol 5(5):343354 Semenza G (2011) Mechanisms of disease oxygen sensing, homeostasis, and disease (vol 365, pg 537, 2011)

July 2012

Correcting low-grade systemic metabolic acidosis with alkali salts, such as sodium bicarbonate or potassium citrate, corrects some of these biochemical consequences (Hazard 1982

One patient even had anaphylaxis

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these results could serve as a foundation for future clinical studies [75]