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Tumor necrosis factor-alpha (TNF-alpha), a cytokine involved in systemic inflammation, along with matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) enzymes that break down extracellular matrix proteins might potentially influence both the inflammatory processes and the remodeling of tissues

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Earlier, we demonstrated that the sEHI, TPPU, minimizes memory impairment in diabetic rats (Watanabe et al., 2008) in diabetes-induced Alzheimers-like complexities

Nicergoline also showed an improving effect on cognitive function in mouse models of Alzheimers disease [68]

2Based on comparison to the national average Annual Percentage Yield (APY) on savings accounts as published in the FDIC National Rates and Rate Caps, accurate as of September 15, 2025

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