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Overall, microbially produced metabolites act as potent CNS regulators, either by modulating the vagus signaling and systemic immunity or by directly crossing the BBB ( 3.7.4 Radiation-induced injuries and microbial mediation Radiation-induced injuries initiate local and systemic responses, which are closely related to the gut microbiome's integrity

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The particular modes of impact might also differ since some risk factors infiltrate biological pathways through gene-environment interactions, while others exert their modifications epigenetically through gene expression impacting phenomenology [16, 281]

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