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Therefore, inhibiting CYP7A1 affects bile acid's ability to eliminate cholesterol and other lipids, leading to the accumulation of total cholesterol, low-density lipoprotein, and triglycerides, which promotes hepatic fat accumulation and the formation of atherosclerotic plaques (Tang et al., 2013)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 39.Noland R.C., Koves T.R., Seiler S.E

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