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Ferroptosis may promote osteoclast bone resorption by inhibiting osteoblast function, thereby affecting the homeostasis and structural integrity of subchondral bone and leading to the occurrence of osteoarthritis (164, 165)

J Biol Chem 281:3976639775

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Protein signal quantification was done with ImageJ (National Institutes of Health)

In contrast, BA did not affect the expression of hsp-6 and hsp-60 genes of the mitochondrial unfolded protein response (UPR-MITO) (Fig