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doi: 10.3389/fendo.2021.645563

Finally, 66,388 cleaned 454 reads with a mean length of 438 16 bp were obtained from the 6 DW biofilm samples

Since low calcium levels usually indicate low vitamin D3, low thyroid, low magnesium, or all three of these issues, if your calcium is low, instead of supplementing with calcium, you probably need to focus on correcting one or all of these issues

You can, but its usually not needed