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Linking these 2 facts, the gene for cystathionine -synthase is located on chromosome 21 and is overexpressed in children with DS [91]

Soares et al

G6PD is functionally active as a dimer or a tetramer 22

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A further mechanism proposed recently is that nitrite-derived NO release by RBCs under hypoxic conditions may contribute to hemostasis via inhibition of PLT aggregation (2, 144)

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