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Excess glucocorticoid exposure suppresses GH secretion mainly through the increase in hypothalamic somatostatin tone, whereas low cortisol levels causes relative GHD that is reversible by glucocorticoid therapy (Giustinas effect) ( Figure 5 ) (104)

Tirzepatide is a delicate molecule

Therapy begins with a consultation and a baseline lab panel so your provider can match the protocol to your biology

10.1016/s0006-8993(01)02100-x 68 KrebsL

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Plasma will be assessed pre- and post-treatment (baseline and three months) as well as every three months during the 9-month no-treatment follow-up period