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Further research into this field will help provide deeper insight into the interaction between the two diseases
A study comparing 152 healthy controls to 161 patients with ischemic stroke found that hyperhomocysteinemia is an independent risk factor for developing ischemic stroke (Parnetti et al

PMID 7569041
TAK-242 is a small-molecule inhibitor of TLR-4 that showed promising results in murine models of LPS-induced acute-on-chronic liver failure (ACLF) [45]
Of the 62 protein kinase inhibitors that are approved by the Food and Drug Administration, over half a dozen of them are TCI, thus, this paradigm shift has become the basis of many current drug discovery programs 2
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