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The clinical titration starts at 0.25 mg weekly and increases every four weeks up to a maintenance dose of 2.4 mg weekly, though some research protocols extend up to 4.5 mg

Yu C, Qi D, Sun J-F et al (2015) Rhein prevents endotoxin-induced acute kidney injury by inhibiting NF-B activities

qPCR was conducted using the LightCycler 480 SYBR Green I Master (Roche

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Furthermore, these studies not only focus on the direct role of ferroptosis in cancer therapy but also explore its synergistic effects in radiotherapy and immunotherapy (140)

doi: 10.1016/j.ejpb.2019.09.016