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[DOI] [PMC free article] [PubMed] [Google Scholar] 105.World Health Organization

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Absent Fn3K, NRF2 is glycated, a post-translational modification which enhances KEAP1-driven degradation, impairs NRF2 binding to transcriptional cofactors sMAF, reduces NRF2 binding in the promoter region of target genes, and leads to reduced transcription of canonical NRF2 pathway genes [87]

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J Trans Med