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PMID: 34571860

Dexpramipexole, the R(+) enantiomer of pramipexole, for the potential treatment of amyotrophic lateral sclerosis

Therefore, SIRT4 may inhibit HIF-1 and inhibit lipid peroxidation and ferroptosis, thereby playing a protective role in SAP

Additionally, pirin (PRI), an iron-binding nuclear protein, plays a critical role in nuclear stress during ferroptosis by downregulating ACSL4 mRNA and its product, AA, thereby inhibiting ACSL4-mediated ferroptosis in PDAC [44]

Michalska et al

Concurrently, TGF-1-mediated fibrous encapsulation drives joint structural remodeling and cartilage degradation ( 2.2 Pathogenesis and pathophysiology of hyperuricemia Hyperuricemia is the precursor state to gout, but its pathophysiological impact extends far beyond the joints, involving multiple systems, including cardiovascular diseases, chronic kidney disease, and metabolic disorders (Figure 2