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Wang P, Yang X, Zhang Z, Song J, Guan Y-F, Zou D-J, et al

Blood-brain barrier and intracerebral progression during breast cancer brain metastasis The brainmetastasis has been shown in the various tumorssuch as lung tumor, breast cancer and melanoma, significantly decreasing the survival of patients [22, 23]

It is worth noting that a breakthrough clinical trial was launched in Japan in 2018 to transplant allogeneic human iPSC-derived dopaminergic neuronal precursors into the striatum of patients with PD [9, 41]

One philosophy: let the science do the work

One such agent is Olorofim, a dihydroorotate dehydrogenase inhibitor currently in advanced clinical development, which impairs mitochondrial pyrimidine biosynthesis, leading to defective DNA synthesis and subsequent fungal cell death (Oliver et al., 2016)

However, as we documented in our metabolic study on the hippocampus, animals with particular protection induced by preischemia, which manifest a general decrease in neuropathological signs of ischemic injury, showed a lower extent of changes in levels of glutamate, GABA, and glutamine, and a faster metabolic recovery comparable to non-protected animals (Baranovicova et al