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Treatment failures have been reported if acetylcysteine was stopped prematurely

[DOI] [PMC free article] [PubMed] [Google Scholar] Steinberg SF

The increase in MnSOD in myocytes subject to adenoviral AC5 KO is abolished by inhibition of either MEK or sirtuin, indicating MnSOD upregulation by both the mitogen-activated protein kinase kinase/extracellular signal-regulated kinases (MEK/ERK) and SIRT1/FoxO3a pathways (Chester and Watts, 2007

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