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The double-blind multicenter phase 3 trials STEP 1, 3, 4, 5 were conducted in adults (mean age 46.247.3 years), mostly females, with obesity or overweight with 1 weight-related complication (mean BMI 37.838.4 kg/m 2 ) and aimed to demonstrate the superiority of semaglutide 2.4 mg over placebo in BW lowering at 68 or 104 24 weeks as an adjunct to diet and physical activity 23

DGEA (Asp-Gly-Glu-Ala) is a recognition motif used by type I collagen to bind to 2 1 integrin [165]

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Recent milestones in tripeptide research further underscore their therapeutic relevance

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Vitamin B12 deficiency is also more prevalent in the elderly, affecting approximately one in 10 people aged 75 or over and one in 20 people aged 65 to 74, according to NHS data