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Critical in execution
The anti-inflammatory effects of sinomenine may occur via the inhibition of pro-inflammatory cytokine and COX-2 production through the inhibition of MAPKs and NF-kB pathway activation by phorbol 12-myristate-13-acetate (PMA) along with A23187 stimulation in HMC-1 cells (human mast cells) (Oh et al
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Because of the essential function of the Wnt/-catenin pathway in human embryonic development and adult tissue homeostasis, the systemic administration of WNT or factors in the Wnt/-catenin pathway may have extensive side effects
Pathological mechanisms underlying single large-scale mitochondrial DNA deletions
