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2019 May 22;11(5):1136

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Central infusion of histamine reduces fat accumulation and upregulates UCP family in leptin-resistant obese mice

[1] [2] This complex absorption mechanism means that deficiency can arise not only from inadequate dietary intake but also from malabsorption disorders

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Yes, if the black stool is due to gastrointestinal bleeding, antacid medications, endoscopic therapy, or surgery may be considered
