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Once in the nucleus, it binds to specific transcription factors and DNA elements particularly antioxidant response elements (ARE) that are regulated by the stress-responsive factor NRF2. Through this mechanism, MOTS-c can turn on a suite of stress-defense and metabolic genes that help cells adapt to high-fat stress or insulin resistance

[1] Always inspect the solution in good light before withdrawing a dose: it should appear clear and free of particles or haze

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They are given as intramuscular injections, usually in the upper arm

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Low concentrations of insulin-like growth factor-I in abdominal obesity