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Because EGCg is a relatively small, lipophilic (fat-soluble) molecule, it possesses the unique ability to cross the blood-brain barrier

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Together, these features may represent leads toward a deeper understanding of ME/CFS: Post-exertional Malaise While ME/CFS patients have very different baseline levels of functionality, they all have one common clinical feature: a distinctly abnormal reaction to stressful events, termed post-exertional malaise (PEM) (Stussman et al., 2020)