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The biological process of fibrosis requires the involvement of activated platelets, macrophages, and myofibroblasts, which in turn, contribute to high levels of transforming growth factor (TGF)-, and the deposition of collagen [7, 8]

FIGURE 5 FIGURE 6 FIGURE 7 Finally, therapy as the recovering effect it has on occluded vessels (Vukojevic et al., 2018

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Furthermore, inhibiting TLR4 can also modulate gut microbiota homeostasis and the MyD88/NF-B axis in ulcerative colitis (164), indicating that TLR4 acts not only as a key sensor of innate immunity but may also regulate neuroimmune crosstalk and gut microenvironment homeostasis

James BD, Wilson RS, Barnes LL, Bennett DA